Assay Detail
Binding
CHEMBL5339368
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Inhibition of c-Met (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of (S)-1-(2-(2,4-difluorophenyl)-4-oxothiazolidin-3-yl)-3-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)urea as a potential anti-colorectal cancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.75 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3188267 | CAPMATINIB | 4.0 | 1 | 9.89 |
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 9.40 |
| CHEMBL2323775 | MK-8033 | 1.0 | 1 | 9.00 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 8.89 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 8.41 |
| CHEMBL2133806 | JNJ-38877605 | 1.0 | 1 | 8.40 |
| CHEMBL3402762 | TEPOTINIB | 4.0 | 1 | 8.40 |
| CHEMBL5414779 | — | — | 1 | 8.22 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3188267 | CAPMATINIB | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL1230609 | FORETINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2323775 | MK-8033 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL2133806 | JNJ-38877605 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3402762 | TEPOTINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5414779 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 8.0 | nM | 8.10 |