Compound Detail
CHEMBL5414779
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Basic Information
| ChEMBL ID | CHEMBL5414779 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DGMFNZXEGKFREH-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
460.4
MW (Da)
4.73
ALogP
5
HBA
3
HBD
96.1
PSA (Ų)
0.40
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 6.0 | nM | 8.22 | Inhibition of c-Met (unknown origin) | 35763868 |
| Tyrosine-protein kinase receptor UFO | IC50 | = | 9.0 | nM | 8.05 | Inhibition of AXL (unknown origin) | 38714043 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35763868 | 10.1016/j.ejmech.2022.114561 | Hepatocyte growth factor receptor | 1 |
| 38714043 | 10.1016/j.ejmech.2024.116475 | Tyrosine-protein kinase receptor UFO | 1 |
Data from ChEMBL 36 via Core Engine