Assay Detail
Binding
CHEMBL5503068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AXL (unknown origin)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent discovery and development of AXL inhibitors as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.87 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | 9.14 |
| CHEMBL5558637 | — | — | 1 | 8.92 |
| CHEMBL3545307 | MERESTINIB | 2.0 | 1 | 8.70 |
| CHEMBL5558810 | — | — | 1 | 8.46 |
| CHEMBL5523430 | — | — | 1 | 8.40 |
| CHEMBL5555517 | — | — | 1 | 8.26 |
| CHEMBL5557693 | — | — | 1 | 8.23 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 8.15 |
| CHEMBL5414779 | — | — | 1 | 8.05 |
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 7.96 |
| CHEMBL3809489 | BEMCENTINIB | 2.0 | 1 | 7.85 |
| CHEMBL5558728 | — | — | 1 | 7.72 |
| CHEMBL2022968 | DUBERMATINIB | 2.0 | 1 | 7.57 |
| CHEMBL5557653 | — | — | 1 | 7.36 |
| CHEMBL3809908 | — | — | 1 | 7.24 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.25 |
| CHEMBL5189859 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301622 | GILTERITINIB | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL5558637 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3545307 | MERESTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5558810 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5523430 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5555517 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5557693 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5414779 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1230609 | FORETINIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3809489 | BEMCENTINIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5558728 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2022968 | DUBERMATINIB | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5557653 | — | IC50 | = | 43.9 | nM | 7.36 |
| CHEMBL3809908 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5189859 | — | IC50 | = | 2600.0 | nM | 5.58 |