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Compound Detail

CHEMBL5555517

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COc1cc2ncnc(Oc3ccc(NC(=O)c4c5n(n(-c6cc(F)ccc6F)c4=O)CCCC5)cc3F)c2cc1OC

Basic Information

ChEMBL ID CHEMBL5555517
Phase Preclinical
Structure Type MOL
InChI Key XUAWXCKJDFXVHP-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

591.5
MW (Da)
5.40
ALogP
9
HBA
1
HBD
109.5
PSA (Ų)
0.27
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H24F3N5O5
MW 591.55
Aromatic Rings 5
Heavy Atoms 43
NP-Likeness -1.38

Activity Summary

IC50 1 meas. best 8.26

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Tyrosine-protein kinase receptor UFO
CHEMBL4895
IC50 8.26 8.26 5.5 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Tyrosine-protein kinase receptor UFO IC50 = 5.5 nM 8.26 Inhibition of AXL (unknown origin) 38714043

Literature References

PubMed DOI Target Context # Activities
38714043 10.1016/j.ejmech.2024.116475 Tyrosine-protein kinase receptor UFO 1

Data from ChEMBL 36 via Core Engine