Assay Detail
Functional
CHEMBL5356783
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Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.78 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5095061 | ELZOVANTINIB | 2.0 | 1 | 9.70 |
| CHEMBL5428302 | — | — | 1 | 8.50 |
| CHEMBL3984441 | NINGETINIB | 2.0 | 1 | 8.15 |
| CHEMBL2133806 | JNJ-38877605 | 1.0 | 1 | 7.73 |
| CHEMBL5275126 | — | — | 1 | 7.60 |
| CHEMBL3039525 | GOLVATINIB | 2.0 | 1 | 7.43 |
| CHEMBL5402276 | — | — | 1 | 6.60 |
| CHEMBL5402147 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5095061 | ELZOVANTINIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5428302 | — | IC50 | = | 3.18 | nM | 8.50 |
| CHEMBL3984441 | NINGETINIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2133806 | JNJ-38877605 | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL5275126 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3039525 | GOLVATINIB | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5402276 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL5402147 | — | IC50 | = | 297.0 | nM | 6.53 |