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Target Snapshot

CHEMBL1844 Target Snapshot

Macrophage colony-stimulating factor 1 receptor · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
4,824Compounds
877Assays
37Approved Drugs
5,164.0Activities
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As of 2026-09-13

Macrophage colony-stimulating factor 1 receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 11 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P07333. Start with neoplasm, then reuse UniProt P07333 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with neoplasm, then reuse UniProt P07333 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 11 linked drugs
Open source guide
Disease program
neoplasm

Macrophage colony-stimulating factor 1 receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 11 linked drugs remain visible in the same block.

Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ARRY-382, AXATILIMAB, EMACTUZUMAB, IMC-CS4. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 11 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Macrophage colony-stimulating factor 1 receptor as ChEMBL target CHEMBL1844, mapped to UniProt P07333. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Macrophage colony-stimulating factor 1 receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1844
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P07333
Macrophage colony-stimulating factor 1 receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Macrophage colony-stimulating factor 1 receptor is the right protein anchor across sources, using UniProt P07333 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 11 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameMacrophage colony-stimulating factor 1 receptor
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP07333
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMacrophage colony-stimulating factor 1 receptor
UniProt AccessionP07333
Component TypeProtein
Sequence Length972 aa

Macrophage colony-stimulating factor 1 receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Macrophage colony-stimulating factor 1 receptor, mapped to UniProt P07333. Sequence length is 972 aa.

Mapped IDP07333
Review nameMacrophage colony-stimulating factor 1 receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Macrophage colony-stimulating factor 1 receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
neoplasm
11 linked drugs · 11 direct · 11 efficacy
Linked drugARRY-382
Linked drugAXATILIMAB
Linked drugEMACTUZUMAB
Linked drugIMC-CS4
Approved-linked Approved
cancer
7 linked drugs · 7 direct · 7 efficacy
Linked drugAMG-820
Linked drugCABIRALIZUMAB
Linked drugEMACTUZUMAB
Linked drugENMD-2076
Approved-linked Approved
renal cell carcinoma
4 linked drugs · 4 direct · 4 efficacy
Linked drugLINIFANIB
Linked drugPAZOPANIB HYDROCHLORIDE
Linked drugSUNITINIB
Linked drugSUNITINIB MALATE
Approved-linked Approved
soft tissue sarcoma
4 linked drugs · 4 direct · 4 efficacy
Linked drugENMD-2076
Linked drugPAZOPANIB HYDROCHLORIDE
Linked drugSUNITINIB
Linked drugSUNITINIB MALATE
Approved-linked Approved
clear cell renal carcinoma
3 linked drugs · 3 direct · 3 efficacy
Linked drugPAZOPANIB HYDROCHLORIDE
Linked drugSUNITINIB
Linked drugSUNITINIB MALATE
Approved-linked Approved
gastrointestinal stromal tumor
3 linked drugs · 3 direct · 3 efficacy
Linked drugPEXIDARTINIB
Linked drugSUNITINIB
Linked drugSUNITINIB MALATE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ARRY-382, AXATILIMAB, EMACTUZUMAB, IMC-CS4. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseneoplasm
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

37
Approved
21
Phase III
35
Phase II
12
Phase I
Assay Mix

Activity Type Distribution

IC503,946.0
KI1,002.0
EC502.0
KD214.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5415149 9.7 IC50 0.2 Preclinical
CHEMBL438533 9.52 IC50 0.3 Preclinical
CHEMBL489684 9.52 IC50 0.3 Preclinical
CHEMBL1171604 9.52 IC50 0.3 Preclinical
CHEMBL5404686 9.52 IC50 0.3 Preclinical
CHEMBL5432649 9.52 IC50 0.3 Preclinical
CHEMBL5434318 9.52 IC50 0.3 Preclinical
CHEMBL5439126 9.52 IC50 0.3 Preclinical
CHEMBL5556952 9.52 IC50 0.3 Preclinical
CHEMBL5563269 9.52 IC50 0.3 Preclinical
Distribution

pChEMBL Value Distribution

82
5.0
196
5.5
401
6.0
470
6.5
459
7.0
772
7.5
717
8.0
482
8.5
172
9.0
19
9.5
pChEMBL
Approved Drugs

Approved Drugs

QUIZARTINIB
CHEMBL576982
Approved 2023
Properties Compare Identifier
PACRITINIB
CHEMBL2035187
Approved 2022
Properties Compare Identifier
FILGOTINIB
CHEMBL3301607
Approved 2020
Properties Compare Identifier
ENTRECTINIB
CHEMBL1983268
Approved 2019
Properties Compare Identifier
FEDRATINIB
CHEMBL1287853
Approved 2019
Properties Compare Identifier
PEXIDARTINIB
CHEMBL3813873
Approved 2019
Properties Compare Identifier
NERATINIB
CHEMBL180022
Approved 2017
Properties Compare Identifier
BRIGATINIB
CHEMBL3545311
Approved 2017
Properties Compare Identifier
MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
NINTEDANIB
CHEMBL502835
Approved 2014
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
BOSUTINIB
CHEMBL288441
Approved 2012
Properties Compare Identifier
AXITINIB
CHEMBL1289926
Approved 2012
Properties Compare Identifier
CRIZOTINIB
CHEMBL601719
Approved 2011
Properties Compare Identifier
PAZOPANIB
CHEMBL477772
Approved 2009
Properties Compare Identifier
NILOTINIB
CHEMBL255863
Approved 2007
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
DASATINIB
CHEMBL5416410
Approved 2006
Properties Compare Identifier
SUNITINIB MALATE
CHEMBL1567
Approved 2006
Properties Compare Identifier
DASATINIB ANHYDROUS
CHEMBL1421
Approved 2006
Properties Compare Identifier
SORAFENIB
CHEMBL1336
Approved 2005
Properties Compare Identifier
IMATINIB
CHEMBL941
Approved 2001
Properties Compare Identifier
Assay Landscape

Assay Landscape

877
Total Assays
2,393
Tested Compounds
3
Assay Types
Binding — 859 assays, 2,393 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 641 1,721 7.7
assay format 109 166 7.7
cell-based format 104 331 7.4
tissue-based format 3 10 6.8
organism-based format 2 165 6.5
Functional — 17 assays, 362 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 1 5.5
assay format 4 361 6.7
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine