Compound Detail
CHEMBL5563269
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5563269 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ISSAIPRVFNYANG-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
401.5
MW (Da)
2.14
ALogP
6
HBA
2
HBD
114.2
PSA (Ų)
0.68
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 9.52 | 9.02 | 0.3 | 2 |
| BaF3 CHEMBL614524 | IC50 | 5.16 | 5.08 | 6900.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 0.3 | nM | 9.52 | Inhibition of CSF1R (unknown origin) using EEEIYGEFE as substrate in presence of... | 38141285 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 3.0 | nM | 8.52 | Inhibition of CSF1R (unknown origin) using ultra ULight GT peptide as substrate ... | 38141285 |
| BaF3 | IC50 | = | 6900.0 | nM | 5.16 | Cytotoxicity against CSF1R-dependent mouse BaF3 cells assessed as reduction in c... | 38141285 |
| BaF3 | IC50 | = | 9900.0 | nM | 5.0 | Cytotoxicity against IL-3-dependent mouse BaF3 cells assessed as reduction in ce... | 38141285 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38141285 | 10.1016/j.ejmech.2023.116053 | Macrophage colony-stimulating factor 1 receptor | 3 |
| 38141285 | 10.1016/j.ejmech.2023.116053 | BaF3 | 2 |
| 38141285 | 10.1016/j.ejmech.2023.116053 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine