Compound Detail
CHEMBL5556952
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Basic Information
| ChEMBL ID | CHEMBL5556952 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SCYRSMZWTVZXCL-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
366.5
MW (Da)
3.02
ALogP
5
HBA
2
HBD
74.3
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 9.52 | 9.1867 | 0.3 | 3 |
| BaF3 CHEMBL614524 | IC50 | 5.82 | 5.41 | 1500.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 0.3 | nM | 9.52 | Inhibition of CSF1R (unknown origin) using EEEIYGEFE as substrate in presence of... | 38141285 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 0.3 | nM | 9.52 | Inhibition of CSF1R (unknown origin) using ultra ULight GT peptide as substrate ... | 38141285 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 3.0 | nM | 8.52 | Inhibition of CSF1R (unknown origin) using ultra ULight GT peptide as substrate ... | 38141285 |
| BaF3 | IC50 | = | 1500.0 | nM | 5.82 | Cytotoxicity against CSF1R-dependent mouse BaF3 cells assessed as reduction in c... | 38141285 |
| BaF3 | IC50 | = | 9900.0 | nM | 5.0 | Cytotoxicity against IL-3-dependent mouse BaF3 cells assessed as reduction in ce... | 38141285 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38141285 | 10.1016/j.ejmech.2023.116053 | Macrophage colony-stimulating factor 1 receptor | 3 |
| 38141285 | 10.1016/j.ejmech.2023.116053 | BaF3 | 2 |
Data from ChEMBL 36 via Core Engine