Compound Detail
CHEMBL5174958
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Basic Information
| ChEMBL ID | CHEMBL5174958 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KCVROOBNYZLDFN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
499.6
MW (Da)
1.79
ALogP
11
HBA
1
HBD
115.9
PSA (Ų)
0.42
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 10.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 10.46 | 10.46 | 0.0 | 1 |
| Hs746T CHEMBL614579 | IC50 | 5.72 | 5.72 | 1900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 0.035 | nM | 10.46 | Inhibition of human recombinant c-MET in presence of ATP by HTRF assay | 33129590 |
| Hs746T | IC50 | = | 1900.0 | nM | 5.72 | Antiproliferative activity against human Hs746T cells assessed as cell growth in... | 33129590 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33129590 | 10.1016/j.ejmech.2020.112946 | Hepatocyte growth factor receptor | 1 |
| 33129590 | 10.1016/j.ejmech.2020.112946 | Hs746T | 1 |
Data from ChEMBL 36 via Core Engine