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Target Snapshot

CHEMBL614579 Target Snapshot

Hs746T · CELL-LINE · Homo sapiens

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62Compounds
21Assays
2Approved Drugs
58.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Hs746T as ChEMBL target CHEMBL614579. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Hs746T
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614579
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Hs746T still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHs746T
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHs746T
UniProt AccessionN/A

Hs746T

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Hs746T.

Review nameHs746T
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC5058.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5181396 9.15 IC50 0.7 Preclinical
CHEMBL5419352 8.82 IC50 1.5 Preclinical
CHEMBL5428302 8.7 IC50 2.0 Preclinical
CHEMBL3402762 8.35 IC50 4.5 Approved
CHEMBL5191797 8.01 IC50 9.8 Preclinical
CHEMBL2105717 8.0 IC50 9.9 Approved
CHEMBL5172104 7.92 IC50 11.9 Preclinical
CHEMBL5177753 7.7 IC50 20.1 Preclinical
CHEMBL3039525 7.64 IC50 23.0 Clinical
CHEMBL5180060 7.64 IC50 22.8 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
7
5.5
11
6.0
14
6.5
4
7.0
4
7.5
3
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEPOTINIB
CHEMBL3402762
Approved 2020
Properties Compare Identifier
CABOZANTINIB
CHEMBL2105717
Approved 2012
Properties Compare Identifier
Assay Landscape

Assay Landscape

21
Total Assays
51
Tested Compounds
1
Assay Types
Functional — 21 assays, 51 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 51 6.7
organism-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine