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Assay Detail

CHEMBL1003889

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human N87 cells after 72 hrs by MTS assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-N87
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-N87 (CHEMBL614197)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.
Kim KS, Zhang L, Schmidt R, Cai ZW, Wei D, Williams DK, Lombardo LJ, Trainor GL, Xie D, Zhang Y, An Y, Sack JS, Tokarski JS, Darienzo C, Kamath A, Marathe P, Zhang Y, Lippy J, Jeyaseelan R, Wautlet B, Henley B, Gullo-Brown J, Manne V, Hunt JT, Fargnoli J, Borzilleri RM.
J Med Chem (2008) 51 : 5330 -5341
PubMed 18690676 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.60 5.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL454356 1 5.91
CHEMBL454357 1 5.58
CHEMBL459876 1 5.31
CHEMBL508006 1 -
CHEMBL452306 1 -
CHEMBL508403 1 -
CHEMBL507573 1 -
CHEMBL451809 1 -
CHEMBL453849 1 -
CHEMBL453850 1 -
CHEMBL454101 1 -
CHEMBL510316 1 -
CHEMBL509101 1 -
CHEMBL459875 1 -
CHEMBL508633 1 -
CHEMBL455386 1 -
CHEMBL503139 1 -
CHEMBL503901 1 -
CHEMBL451789 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL454356 IC50 = 1240.0 nM 5.91
CHEMBL454357 IC50 = 2615.0 nM 5.58
CHEMBL459876 IC50 = 4900.0 nM 5.31
CHEMBL508006 IC50 - -
CHEMBL452306 IC50 - -
CHEMBL508403 IC50 - -
CHEMBL507573 IC50 - -
CHEMBL451809 IC50 > 5000.0 nM -
CHEMBL453849 IC50 > 5000.0 nM -
CHEMBL453850 IC50 > 5000.0 nM -
CHEMBL454101 IC50 > 5000.0 nM -
CHEMBL510316 IC50 > 5000.0 nM -
CHEMBL509101 IC50 > 5000.0 nM -
CHEMBL459875 IC50 > 5000.0 nM -
CHEMBL508633 IC50 > 5000.0 nM -
CHEMBL455386 IC50 > 5000.0 nM -
CHEMBL503139 IC50 > 5000.0 nM -
CHEMBL503901 IC50 > 5000.0 nM -
CHEMBL451789 IC50 - -