Assay Detail
Binding
CHEMBL1004121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant caspase 3 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 mins
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.49 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293034 | — | — | 1 | 8.62 |
| CHEMBL493375 | — | — | 1 | 8.44 |
| CHEMBL523666 | — | — | 1 | 8.18 |
| CHEMBL513663 | — | — | 1 | 8.03 |
| CHEMBL467252 | — | — | 1 | 8.00 |
| CHEMBL511723 | — | — | 1 | 7.96 |
| CHEMBL62993 | — | — | 1 | 7.77 |
| CHEMBL513297 | — | — | 1 | 7.77 |
| CHEMBL524017 | — | — | 1 | 7.72 |
| CHEMBL521984 | — | — | 1 | 7.64 |
| CHEMBL512101 | — | — | 1 | 7.60 |
| CHEMBL468088 | — | — | 1 | 7.51 |
| CHEMBL494220 | — | — | 1 | 7.38 |
| CHEMBL467251 | — | — | 1 | 7.37 |
| CHEMBL513513 | — | — | 1 | 7.13 |
| CHEMBL492385 | — | — | 1 | 7.10 |
| CHEMBL60190 | — | — | 1 | 7.07 |
| CHEMBL466422 | — | — | 1 | 6.84 |
| CHEMBL493374 | — | — | 1 | 6.82 |
| CHEMBL466423 | — | — | 1 | 6.56 |
| CHEMBL466007 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293034 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL493375 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL523666 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL513663 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL467252 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL511723 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL62993 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL513297 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL524017 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL521984 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL512101 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL468088 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL494220 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL467251 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL513513 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL492385 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL60190 | — | IC50 | = | 84.9 | nM | 7.07 |
| CHEMBL466422 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL493374 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL466423 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL466007 | — | IC50 | = | 1880.0 | nM | 5.73 |