Assay Detail
Functional
CHEMBL1004216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction plaque formation after 3 days
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.23 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1257073 | TECOVIRIMAT | 4.0 | 1 | 7.30 |
| CHEMBL203321 | BRINCIDOFOVIR | 4.0 | 1 | 6.85 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1257073 | TECOVIRIMAT | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL203321 | BRINCIDOFOVIR | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 29200.0 | nM | 4.54 |