Assay Detail
ADMET
CHEMBL1004564
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human CEM cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.25 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.72 |
| CHEMBL189355 | — | — | 1 | 7.13 |
| CHEMBL524986 | — | — | 1 | 7.05 |
| CHEMBL496320 | — | — | 1 | 6.36 |
| CHEMBL526096 | — | — | 1 | 6.14 |
| CHEMBL447202 | — | — | 1 | 6.00 |
| CHEMBL496117 | — | — | 1 | 5.92 |
| CHEMBL448931 | — | — | 1 | 5.85 |
| CHEMBL498170 | — | — | 1 | 5.77 |
| CHEMBL495517 | — | — | 1 | 5.75 |
| CHEMBL522049 | — | — | 1 | 5.17 |
| CHEMBL523396 | — | — | 1 | 5.08 |
| CHEMBL498195 | — | — | 1 | - |
| CHEMBL495931 | — | — | 1 | - |
| CHEMBL496958 | — | — | 1 | - |
| CHEMBL496751 | — | — | 1 | - |
| CHEMBL495716 | — | — | 1 | - |
| CHEMBL522047 | — | — | 1 | - |
| CHEMBL495509 | — | — | 1 | - |
| CHEMBL498589 | — | — | 1 | - |
| CHEMBL525737 | — | — | 1 | - |
| CHEMBL496118 | — | — | 1 | - |
| CHEMBL497356 | — | — | 1 | - |
| CHEMBL497566 | — | — | 1 | - |
| CHEMBL497381 | — | — | 1 | - |
| CHEMBL497975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL189355 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL524986 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL496320 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL526096 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL447202 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL496117 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL448931 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL498170 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL495517 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL522049 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL523396 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL498195 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL495931 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL496958 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL496751 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL495716 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL522047 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL495509 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL498589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL525737 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL496118 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497356 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497566 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497381 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497975 | — | IC50 | > | 10000.0 | nM | - |