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Assay Detail

CHEMBL1004838

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Binding
Inhibition of ACE
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Angiotensin-converting enzyme (CHEMBL1808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.
Enomoto H, Morikawa Y, Miyake Y, Tsuji F, Mizuchi M, Suhara H, Fujimura K, Horiuchi M, Ban M.
Bioorg Med Chem Lett (2008) 18 : 4529 -4532
PubMed 18674901 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 8.30 10.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL443353 1 10.54
CHEMBL526298 1 9.74
CHEMBL499612 1 9.05
CHEMBL500408 1 8.64
CHEMBL498798 1 8.62
CHEMBL526896 1 8.49
CHEMBL499305 1 8.48
CHEMBL525967 1 8.39
CHEMBL499610 1 8.38
CHEMBL449792 1 8.08
CHEMBL499611 1 7.82
CHEMBL525948 1 7.72
CHEMBL1560 CAPTOPRIL 4.0 1 7.64
CHEMBL502817 1 6.55
CHEMBL500409 1 6.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL443353 IC50 = 0.029 nM 10.54
CHEMBL526298 IC50 = 0.18 nM 9.74
CHEMBL499612 IC50 = 0.9 nM 9.05
CHEMBL500408 IC50 = 2.3 nM 8.64
CHEMBL498798 IC50 = 2.4 nM 8.62
CHEMBL526896 IC50 = 3.2 nM 8.49
CHEMBL499305 IC50 = 3.3 nM 8.48
CHEMBL525967 IC50 = 4.1 nM 8.39
CHEMBL499610 IC50 = 4.2 nM 8.38
CHEMBL449792 IC50 = 8.4 nM 8.08
CHEMBL499611 IC50 = 15.0 nM 7.82
CHEMBL525948 IC50 = 19.0 nM 7.72
CHEMBL1560 CAPTOPRIL IC50 = 23.0 nM 7.64
CHEMBL502817 IC50 = 280.0 nM 6.55
CHEMBL500409 IC50 = 410.0 nM 6.39