Angiotensin-converting enzyme · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Angiotensin-converting enzyme shows approved-linked disease relevance led by hypertension. 5 more disease programs remain visible in the same review block. 14 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P12821. Start with hypertension, then reuse UniProt P12821 as the stable protein anchor across project notes and exports.
Start with hypertension, then reuse UniProt P12821 as the stable protein anchor across project notes and exports.
Angiotensin-converting enzyme shows approved-linked disease relevance led by hypertension. 5 more disease programs remain visible in the same review block. 14 linked drugs remain visible in the same block.
Start review with hypertension because it currently carries approved-linked support. Linked drugs include BENAZEPRIL HYDROCHLORIDE, CAPTOPRIL, DELAPRIL, ENALAPRIL MALEATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAngiotensin-converting enzyme
Review this target as Angiotensin-converting enzyme, mapped to UniProt P12821. Sequence length is 1306 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Angiotensin-converting enzyme as ChEMBL target CHEMBL1808, mapped to UniProt P12821. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Angiotensin-converting enzyme is the right protein anchor across sources, using UniProt P12821 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hypertension is currently framed as approved-linked support. It currently carries 14 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Angiotensin-converting enzyme |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P12821 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Angiotensin-converting enzyme |
| UniProt Accession | P12821 |
| Component Type | Protein |
| Sequence Length | 1306 aa |
Angiotensin-converting enzyme
Review this target as Angiotensin-converting enzyme, mapped to UniProt P12821. Sequence length is 1306 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Angiotensin-converting enzyme shows approved-linked disease relevance led by hypertension. 5 more disease programs remain visible in the same review block.
Start review with hypertension because it currently carries approved-linked support. Linked drugs include BENAZEPRIL HYDROCHLORIDE, CAPTOPRIL, DELAPRIL, ENALAPRIL MALEATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL289556 | 10.82 | Ki | 0.015 | Clinical |
| CHEMBL443353 | 10.54 | IC50 | 0.029 | Preclinical |
| CHEMBL1237 | 10.0 | IC50 | 0.1 | Approved |
| CHEMBL289556 | 10.0 | IC50 | 0.1 | Clinical |
| CHEMBL198316 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL35561 | 9.94 | IC50 | 0.1148 | Preclinical |
| CHEMBL1560 | 9.92 | IC50 | 0.12 | Approved |
| CHEMBL35309 | 9.88 | IC50 | 0.1318 | Preclinical |
| CHEMBL1788109 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL526298 | 9.74 | IC50 | 0.18 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 207 | 496 | 7.0 |
| cell-based format | 12 | 12 | 7.1 |
| tissue-based format | 7 | 39 | 6.4 |
| cell-free format | 5 | 19 | 6.5 |
| protein format | 4 | 55 | 6.8 |
| assay format | 3 | 33 | 7.5 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 4 | 7.1 |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 126 | 7.2 |
| organism-based format | 1 | 0 | — |