Compound Detail
CHEMBL1519
TRANDOLAPRIL 💊 Approved Drug
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💊 Approved Drug
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@H]2CCCC[C@@H]21
Basic Information
| ChEMBL ID | CHEMBL1519 |
| Name | TRANDOLAPRIL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | VXFJYXUZANRPDJ-WTNASJBWSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL1201387 |
1
Targets
1
Activities
1
Assay Types
9
PK Parameters
20
Publications
9
Known Names
5
Indications
1
Mechanisms
Molecular Properties
430.6
MW (Da)
2.77
ALogP
5
HBA
2
HBD
95.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1996 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Angiotensin-converting enzyme inhibitor | INHIBITOR | Angiotensin-converting enzyme | ✓ | ✓ |
Indications
Cardiovascular Diseases Heart Failure Hypertension Myocardial Infarction Ventricular Dysfunction, Left
ATC Classification
C09AA10
trandolapril
Level 1: CARDIOVASCULAR SYSTEM
Level 2: AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Drug Warnings
Black Box Warning
teratogenicity
Activity Summary
IC50 1 meas. best 9.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL1808 | IC50 | 9.03 | 9.03 | 0.9 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL_renal | 1.0 | L/hr | Homo sapiens |
| F | 10.0 | % | Homo sapiens |
| F | 10.0 | % | Homo sapiens |
| T1/2 | 6.0 | hr | Homo sapiens |
| T1/2 | 0.3333 | hr | Homo sapiens |
| T1/2 | 0.1167 | hr | Rattus norvegicus |
| Tmax | 1.0 | hr | Homo sapiens |
| Total CL | 52.0 | L/hr | Homo sapiens |
| Vd | 18.0 | L | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | IC50 | = | 0.93 | nM | 9.03 | Inhibitory activity against angiotensin I converting enzyme (ACE) | 10669559 |
Literature References
Data from ChEMBL 36 via Core Engine