Assay Detail
Binding
CHEMBL648689
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Inhibitory activity against angiotensin I converting enzyme (ACE)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Protease inhibitors: current status and future prospects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.26 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331378 | ZOFENOPRIL | 2.0 | 1 | 9.40 |
| CHEMBL1519 | TRANDOLAPRIL | 4.0 | 1 | 9.03 |
| CHEMBL3039598 | FOSINOPRIL | 4.0 | 1 | 9.00 |
| CHEMBL838 | BENAZEPRIL | 4.0 | 1 | 8.77 |
| CHEMBL1165 | MOEXIPRIL | 4.0 | 1 | 8.59 |
| CHEMBL1168 | RAMIPRIL | 4.0 | 1 | 8.40 |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 8.35 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | 4.0 | 1 | 8.33 |
| CHEMBL325056 | — | — | 1 | 8.30 |
| CHEMBL1592 | QUINAPRIL | 4.0 | 1 | 8.08 |
| CHEMBL114658 | — | — | 1 | 7.92 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.72 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.64 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 6.07 |
| CHEMBL113759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331378 | ZOFENOPRIL | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1519 | TRANDOLAPRIL | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL3039598 | FOSINOPRIL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL838 | BENAZEPRIL | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1165 | MOEXIPRIL | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1168 | RAMIPRIL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL578 | ENALAPRIL | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL325056 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1592 | QUINAPRIL | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL114658 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL191 | LOSARTAN | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL10247 | THIORPHAN | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL113759 | — | IC50 | > | 10000.0 | nM | - |