Compound Detail
CHEMBL1592
QUINAPRIL 💊 Approved Drug
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💊 Approved Drug
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)O
Basic Information
| ChEMBL ID | CHEMBL1592 |
| Name | QUINAPRIL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | JSDRRTOADPPCHY-HSQYWUDLSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL1733 |
3
Targets
8
Activities
1
Assay Types
1
PK Parameters
20
Publications
2
Known Names
2
Indications
Molecular Properties
438.5
MW (Da)
2.57
ALogP
5
HBA
2
HBD
95.9
PSA (Ų)
0.58
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1991 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Cardiovascular Diseases Diabetes Mellitus, Type 1
ATC Classification
C09AA06
quinapril
Level 1: CARDIOVASCULAR SYSTEM
Level 2: AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Activity Summary
IC50 8 meas. best 8.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL1808 | IC50 | 8.08 | 8.08 | 8.3 | 4 |
| Angiotensin-converting enzyme CHEMBL4074 | IC50 | 6.96 | 6.18 | 110.0 | 2 |
| Bile salt export pump CHEMBL6020 | IC50 | 4.81 | 4.42 | 15500.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 8.5 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine