Assay Detail
Binding
CHEMBL648701
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In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.59 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1592 | QUINAPRIL | 4.0 | 1 | 8.08 |
| CHEMBL25782 | — | — | 1 | 7.85 |
| CHEMBL284898 | — | — | 1 | 7.62 |
| CHEMBL26226 | — | — | 1 | 7.07 |
| CHEMBL2079671 | — | — | 1 | 7.00 |
| CHEMBL285897 | — | — | 1 | 6.96 |
| CHEMBL1907755 | — | — | 1 | 6.85 |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 6.85 |
| CHEMBL1907752 | — | — | 1 | 6.66 |
| CHEMBL284494 | — | — | 1 | 6.66 |
| CHEMBL2079670 | — | — | 1 | 6.58 |
| CHEMBL1733 | QUINAPRILAT | 2.0 | 1 | 6.55 |
| CHEMBL1907754 | — | — | 1 | 6.34 |
| CHEMBL1907762 | — | — | 1 | 6.24 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 5.89 |
| CHEMBL1907760 | — | — | 1 | 5.70 |
| CHEMBL25996 | — | — | 1 | 5.54 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 5.51 |
| CHEMBL1907759 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1592 | QUINAPRIL | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL25782 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL284898 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL26226 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2079671 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL285897 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1907755 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL578 | ENALAPRIL | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1907752 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL284494 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2079670 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1733 | QUINAPRILAT | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1907754 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1907762 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1907760 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL25996 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1907759 | — | IC50 | = | 4800.0 | nM | 5.32 |