Assay Detail
Binding
CHEMBL648350
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Inhibition of guinea pig angiotensin I converting enzyme
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.42 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.62 |
| CHEMBL1733 | QUINAPRILAT | 2.0 | 1 | 8.55 |
| CHEMBL58042 | — | — | 1 | 8.52 |
| CHEMBL58480 | — | — | 1 | 8.51 |
| CHEMBL61811 | — | — | 1 | 8.24 |
| CHEMBL1592 | QUINAPRIL | 4.0 | 1 | 8.08 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.89 |
| CHEMBL279737 | — | — | 1 | 7.75 |
| CHEMBL2115478 | — | — | 1 | 7.36 |
| CHEMBL1165 | MOEXIPRIL | 4.0 | 1 | 7.25 |
| CHEMBL58720 | — | — | 1 | 6.89 |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 6.85 |
| CHEMBL2114322 | — | — | 1 | 6.70 |
| CHEMBL58340 | — | — | 1 | 6.52 |
| CHEMBL412893 | — | — | 1 | 6.36 |
| CHEMBL60702 | — | — | 1 | 6.28 |
| CHEMBL2115075 | — | — | 1 | 5.96 |
| CHEMBL2115288 | — | — | 1 | 5.21 |
| CHEMBL62203 | — | — | 1 | 4.85 |
| CHEMBL61137 | — | — | 1 | 4.66 |
| CHEMBL57200 | — | — | 1 | 4.62 |
| CHEMBL59354 | — | — | 1 | 4.32 |
| CHEMBL57202 | — | — | 1 | 4.31 |
| CHEMBL61916 | — | — | 1 | 4.24 |
| CHEMBL417226 | — | — | 1 | 4.24 |
| CHEMBL3350318 | — | — | 1 | 4.05 |
| CHEMBL57201 | — | — | 1 | - |
| CHEMBL2115076 | — | — | 1 | - |
| CHEMBL291552 | — | — | 1 | - |
| CHEMBL59401 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1733 | QUINAPRILAT | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL58042 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL58480 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL61811 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1592 | QUINAPRIL | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL279737 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2115478 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1165 | MOEXIPRIL | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL58720 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL578 | ENALAPRIL | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2114322 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL58340 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL412893 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL60702 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2115075 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2115288 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL62203 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL61137 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL57200 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL59354 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL57202 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL61916 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL417226 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL3350318 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL57201 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2115076 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL291552 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL59401 | — | IC50 | - | nM | - |