Compound Detail
CHEMBL1165
MOEXIPRIL 💊 Approved Drug
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💊 Approved Drug
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1Cc2cc(OC)c(OC)cc2C[C@H]1C(=O)O
Basic Information
| ChEMBL ID | CHEMBL1165 |
| Name | MOEXIPRIL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | UWWDHYUMIORJTA-HSQYWUDLSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL1201405 |
1
Targets
2
Activities
1
Assay Types
2
PK Parameters
20
Publications
3
Known Names
2
Indications
Molecular Properties
498.6
MW (Da)
2.58
ALogP
7
HBA
2
HBD
114.4
PSA (Ų)
0.45
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1995 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Cardiovascular Diseases Liver Cirrhosis, Biliary
ATC Classification
C09AA13
moexipril
Level 1: CARDIOVASCULAR SYSTEM
Level 2: AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Activity Summary
IC50 2 meas. best 8.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL1808 | IC50 | 8.59 | 7.92 | 2.6 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 8.0 | mL.min-1.g-1 | Homo sapiens |
| F | 13.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | IC50 | = | 2.6 | nM | 8.59 | Inhibitory activity against angiotensin I converting enzyme (ACE) | 10669559 |
| Angiotensin-converting enzyme | IC50 | = | 56.0 | nM | 7.25 | Inhibition of guinea pig angiotensin I converting enzyme | 3020249 |
Literature References
Data from ChEMBL 36 via Core Engine