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Assay Detail

CHEMBL1909192

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG)
ChEMBL ↗
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Tissue Lung
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Angiotensin-converting enzyme (CHEMBL4074) ↗
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

DrugMatrix in vitro pharmacology data
Scott S. Auerbach, DrugMatrix¨ and ToxFX¨ Coordinator National Toxicology Program

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 871 6.38 8.22
Ki 871 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1237 LISINOPRIL ANHYDROUS 4.0 2 8.22
CHEMBL1560 CAPTOPRIL 4.0 2 6.89
CHEMBL4649901 BLEOMYCIN A2 — 2 6.23
CHEMBL86754 IODOQUINOL 2.0 2 6.04
CHEMBL578 ENALAPRIL 4.0 2 5.48
CHEMBL1592 QUINAPRIL 4.0 2 5.40
CHEMBL701 BACLOFEN 4.0 2 -
CHEMBL1201346 BALSALAZIDE 4.0 2 -
CHEMBL221753 BENZETHONIUM CHLORIDE 2.0 2 -
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER — 2 -
CHEMBL277474 ANTIPYRINE 3.0 2 -
CHEMBL415690 BETADEX 3.0 2 -
CHEMBL264374 BEZAFIBRATE 3.0 2 -
CHEMBL1077 BROMFENAC 4.0 2 -
CHEMBL894 BUPROPION 4.0 2 -
CHEMBL108 CARBAMAZEPINE 4.0 2 -
CHEMBL24 ATENOLOL 4.0 2 -
CHEMBL1598608 AZASETRON 2.0 2 -
CHEMBL1095699 AZASERINE 2.0 2 -
CHEMBL3084803 ASTROMICIN 2.0 2 -
CHEMBL1200396 BUPIVACAINE HYDROCHLORIDE 4.0 2 -
CHEMBL844 BRIMONIDINE 4.0 2 -
CHEMBL1231530 BETAMIPRON 2.0 2 -
CHEMBL12089 BERBERINE CHLORIDE 1.0 2 -
CHEMBL211501 ANTIMYCIN A — 2 -
CHEMBL14 CARBACHOL 4.0 2 -
CHEMBL1458880 CADMIUM DICHLORIDE — 2 -
CHEMBL388590 BENZBROMARONE 4.0 2 -
CHEMBL1200558 BACITRACIN 4.0 2 -
CHEMBL515914 AZARIBINE 4.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1237 LISINOPRIL ANHYDROUS IC50 = 6.038 nM 8.22
CHEMBL1560 CAPTOPRIL IC50 = 130.0 nM 6.89
CHEMBL4649901 BLEOMYCIN A2 IC50 = 588.0 nM 6.23
CHEMBL86754 IODOQUINOL IC50 = 906.0 nM 6.04
CHEMBL578 ENALAPRIL IC50 = 3330.0 nM 5.48
CHEMBL1592 QUINAPRIL IC50 = 4008.0 nM 5.40
CHEMBL80 NALOXONE IC50 - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 Ki - — -
CHEMBL80 NALOXONE Ki - — -
CHEMBL1221512 — IC50 - — -
CHEMBL1221512 — Ki - — -
CHEMBL480 LANSOPRAZOLE IC50 - — -
CHEMBL480 LANSOPRAZOLE Ki - — -
CHEMBL1201193 LEVOBUPIVACAINE IC50 - — -
CHEMBL64391 ITRACONAZOLE Ki - — -
CHEMBL1909067 — IC50 - — -
CHEMBL1201139 MEGESTROL ACETATE Ki - — -
CHEMBL1373 MODAFINIL Ki - — -
CHEMBL1373 MODAFINIL IC50 - — -
CHEMBL91 MICONAZOLE Ki - — -
CHEMBL91 MICONAZOLE IC50 - — -
CHEMBL503 LOVASTATIN Ki - — -
CHEMBL503 LOVASTATIN IC50 - — -
CHEMBL1201151 MESTRANOL IC50 - — -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE Ki - — -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE IC50 - — -
CHEMBL1201151 MESTRANOL Ki - — -
CHEMBL86 METOCLOPRAMIDE IC50 - — -
CHEMBL6437 MIANSERIN Ki - — -
CHEMBL1909067 — Ki - — -
CHEMBL19019 NALTREXONE IC50 - — -
CHEMBL19019 NALTREXONE Ki - — -
CHEMBL165790 IPRIFLAVONE IC50 - — -
CHEMBL165790 IPRIFLAVONE Ki - — -
CHEMBL547 ISOTRETINOIN IC50 - — -
CHEMBL547 ISOTRETINOIN Ki - — -
CHEMBL191 LOSARTAN IC50 - — -
CHEMBL191 LOSARTAN Ki - — -
CHEMBL6437 MIANSERIN IC50 - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 IC50 - — -
CHEMBL86304 MOCLOBEMIDE IC50 - — -
CHEMBL86304 MOCLOBEMIDE Ki - — -
CHEMBL1618305 NALOXONAZINE IC50 - — -
CHEMBL1618305 NALOXONAZINE Ki - — -
CHEMBL2106399 KITASAMYCIN IC50 - — -
CHEMBL2106399 KITASAMYCIN Ki - — -
CHEMBL741 LAMOTRIGINE IC50 - — -
CHEMBL741 LAMOTRIGINE Ki - — -
CHEMBL1201237 LEVOBUNOLOL IC50 - — -
CHEMBL1201237 LEVOBUNOLOL Ki - — -