Compound Detail
CHEMBL4649901
BLEOMYCIN A2 Enter ChEMBL ID:
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Cc1c(N)nc([C@H](CC(N)=O)NC[C@H](N)C(N)=O)nc1C(=O)N[C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@H](C(=O)NCCc1nc(-c2nc(C(=O)NCCC[S+](C)C)cs2)cs1)[C@@H](C)O)[C@@H](O[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](OC(N)=O)[C@@H]1O)c1c[nH]cn1.[Br-]
Basic Information
| ChEMBL ID | CHEMBL4649901 |
| Name | BLEOMYCIN A2 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SMTAKYAVPSGWEV-OYALTWQYSA-N |
| Parent Compound | CHEMBL403664 |
| Active Moiety | CHEMBL403664 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1415.6
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.23
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL4074 | IC50 | 6.23 | 6.23 | 588.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | IC50 | = | 588.0 | nM | 6.23 | DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrat... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3885881 | Rattus norvegicus | 408 |
| 2433447 | 10.1021/jm00384a003 | B16 | 2 |
| - | 10.1016/S0960-894X(00)80449-7 | Nucleic Acid | 2 |
| - | 10.1016/S0960-894X(00)80449-7 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine