Assay Detail
Binding
CHEMBL3586838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Design, synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin Converting Enzyme (ACE) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.56 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3585803 | — | — | 1 | 7.00 |
| CHEMBL838 | BENAZEPRIL | 4.0 | 1 | 7.00 |
| CHEMBL1592 | QUINAPRIL | 4.0 | 1 | 6.96 |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 6.91 |
| CHEMBL1168 | RAMIPRIL | 4.0 | 1 | 6.60 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | 4.0 | 1 | 6.50 |
| CHEMBL3585794 | — | — | 1 | 6.28 |
| CHEMBL3585792 | — | — | 1 | 6.19 |
| CHEMBL3585802 | — | — | 1 | 6.18 |
| CHEMBL3585799 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3585803 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL838 | BENAZEPRIL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1592 | QUINAPRIL | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL578 | ENALAPRIL | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL1168 | RAMIPRIL | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL3585794 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL3585792 | — | IC50 | = | 647.0 | nM | 6.19 |
| CHEMBL3585802 | — | IC50 | = | 657.0 | nM | 6.18 |
| CHEMBL3585799 | — | IC50 | = | 1120.0 | nM | 5.95 |