Compound Detail
CHEMBL838
BENAZEPRIL 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL838 |
| Name | BENAZEPRIL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XPCFTKFZXHTYIP-PMACEKPBSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL1192519 |
3
Targets
7
Activities
1
Assay Types
2
PK Parameters
20
Publications
9
Known Names
9
Indications
Molecular Properties
424.5
MW (Da)
2.57
ALogP
5
HBA
2
HBD
95.9
PSA (Ų)
0.60
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1991 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Cardiovascular Diseases Atherosclerosis Coronary Disease Diabetes Mellitus Diabetes Mellitus, Type 2 Hypercholesterolemia Hypertension Lupus Erythematosus, Systemic Nephritis, Hereditary
ATC Classification
C09AA07
benazepril
Level 1: CARDIOVASCULAR SYSTEM
Level 2: AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Activity Summary
IC50 7 meas. best 8.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL1808 | IC50 | 8.77 | 8.77 | 1.7 | 1 |
| Angiotensin-converting enzyme CHEMBL2625 | IC50 | 8.77 | 8.77 | 1.7 | 1 |
| Angiotensin-converting enzyme CHEMBL4074 | IC50 | 8.7 | 7.4567 | 2.0 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 52.5 | mL.min-1.g-1 | Homo sapiens |
| F | 37.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | IC50 | = | 1.7 | nM | 8.77 | In vitro inhibitory activity against Angiotensin I converting enzyme | 2999394 |
| Angiotensin-converting enzyme | IC50 | = | 1.7 | nM | 8.77 | Inhibitory activity against angiotensin I converting enzyme (ACE) | 10669559 |
| Angiotensin-converting enzyme | IC50 | = | 2.0 | nM | 8.7 | Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from ra... | 8021921 |
| Angiotensin-converting enzyme | IC50 | = | 100.0 | nM | 7.0 | Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis a... | 25922179 |
| Angiotensin-converting enzyme | IC50 | = | 212.0 | nM | 6.67 | Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucin... | 23777825 |
Literature References
Data from ChEMBL 36 via Core Engine