Assay Detail
Binding
CHEMBL648447
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Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Dual angiotensin converting enzyme/thromboxane synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.04 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 8.70 |
| CHEMBL838 | BENAZEPRIL | 4.0 | 1 | 8.70 |
| CHEMBL55763 | — | — | 1 | 8.40 |
| CHEMBL301130 | — | — | 1 | 8.22 |
| CHEMBL51756 | — | — | 1 | 8.22 |
| CHEMBL53630 | — | — | 1 | 8.15 |
| CHEMBL297026 | — | — | 1 | 8.15 |
| CHEMBL301505 | — | — | 1 | 8.10 |
| CHEMBL299309 | — | — | 1 | 8.00 |
| CHEMBL53709 | — | — | 1 | 8.00 |
| CHEMBL300130 | — | — | 1 | 7.92 |
| CHEMBL301730 | — | — | 1 | 7.70 |
| CHEMBL53754 | — | — | 1 | 7.70 |
| CHEMBL54520 | — | — | 1 | 7.52 |
| CHEMBL296151 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL578 | ENALAPRIL | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL838 | BENAZEPRIL | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55763 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL301130 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL51756 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL53630 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL297026 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL301505 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL299309 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL53709 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL300130 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL301730 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL53754 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL54520 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL296151 | — | IC50 | = | 90.0 | nM | 7.05 |