Compound Detail
CHEMBL1192519
BENAZEPRILAT 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1192519 |
| Name | BENAZEPRILAT |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | MADRIHWFJGRSBP-ROUUACIJSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
6
Known Names
Molecular Properties
396.4
MW (Da)
2.09
ALogP
4
HBA
3
HBD
106.9
PSA (Ų)
0.63
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 2 meas. best 8.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL1808 | IC50 | 8.77 | 8.77 | 1.7 | 1 |
| Angiotensin-converting enzyme CHEMBL4074 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | IC50 | = | 1.7 | nM | 8.77 | Inhibition of angiotensin-converting enzyme (unknown origin) | 27690430 |
| Angiotensin-converting enzyme | IC50 | = | 2.0 | nM | 8.7 | Tested in vitro for the inhibition against angiotensin converting enzyme (ACE) f... | 8254612 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8544178 | 10.1021/jm00026a009 | Angiotensin-converting enzyme | 4 |
| 8254612 | 10.1021/jm00076a010 | Rattus norvegicus | 3 |
| 8254612 | 10.1021/jm00076a010 | Angiotensin-converting enzyme | 1 |
| 27690430 | 10.1021/acs.jmedchem.6b01029 | Angiotensin-converting enzyme | 1 |
Data from ChEMBL 36 via Core Engine