Assay Detail

CHEMBL1004915

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Binding

Inhibition of Enterobacter cloacae IMI1 beta lactamase expressed in Escherichia coli DH5alpha by SDS-PAGE

ChEMBL ↗

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Target

IMI-1 (CHEMBL5219) ↗

Open DB target context

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IMI-1 (CHEMBL5219) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target IMI-1

CHEMBL5219

Anchored from Assay target.

Protein identity IMI-1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Enterobacter cloacae
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

IMI-1 (CHEMBL5219) ↗

Type	SINGLE PROTEIN
Organism	Enterobacter cloacae

Publication

Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase.

Fonseca F, Sarmento AC, Henriques I, Samyn B, van Beeumen J, Domingues P, Domingues MR, Saavedra MJ, Correia A.
Antimicrob Agents Chemother (2007) 51 : 4512 -4514
PubMed 17875998 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.52	7.52
Activity	1	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL404	TAZOBACTAM	4.0	1	7.52
CHEMBL858	EDETIC ACID	3.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL404	TAZOBACTAM	IC50	=	30.0	nM	7.52
CHEMBL858	EDETIC ACID	Activity		-	—	-