Assay Detail
Functional
CHEMBL1005706
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Inhibition of cytochalasin B and fMLP-stimulated human neutrophil degranulation assessed as inhibition of elastase release preincubated for 5 mins before cytochalasin B and fMLP challenge measured after 20 mins by microtiter plate assay
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.59 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517216 | DYSIDINE | — | 2 | 5.89 |
| CHEMBL477692 | BOLINAQUINONE | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517216 | DYSIDINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL477692 | BOLINAQUINONE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL517216 | DYSIDINE | IC50 | - | — | - |