Assay Detail
Binding
CHEMBL1006039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human muscarinic M4 receptor expressed in insect Sf9 cells
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.98 | 5.98 |
| Ki | 1 | 6.85 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499519 | NOCARDIMICIN B | — | 2 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499519 | NOCARDIMICIN B | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL499519 | NOCARDIMICIN B | IC50 | = | 1040.0 | nM | 5.98 |