Assay Detail
Functional
CHEMBL1006155
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Vasorelaxant activity in rat bladder assessed as inhibition of carbachol-induced contraction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Urinary bladder |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.58 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11458 | — | — | 1 | 6.85 |
| CHEMBL473744 | — | — | 1 | 5.69 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 5.01 |
| CHEMBL491091 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11458 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL473744 | — | EC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 9820.0 | nM | 5.01 |
| CHEMBL491091 | — | EC50 | = | 17700.0 | nM | 4.75 |