Assay Detail
Binding
CHEMBL1006192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to RYR1 channels by calcium mobilization assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.27 | 5.66 |
| IC50 | 1 | 5.22 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439151 | BASTADIN 5 | — | 1 | 5.66 |
| CHEMBL213853 | — | — | 1 | 5.22 |
| CHEMBL360190 | BASTADIN 7 | — | 1 | 5.20 |
| CHEMBL386905 | — | — | 1 | 4.96 |
| CHEMBL506286 | BASTADIN 19 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439151 | BASTADIN 5 | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL213853 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL360190 | BASTADIN 7 | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL386905 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL506286 | BASTADIN 19 | EC50 | > | 100000.0 | nM | - |