Compound Detail
CHEMBL506286
BASTADIN 19 Enter ChEMBL ID:
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O=C1NCCc2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)CCNC(=O)/C(=N/O)Cc2cc(Br)c(O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O
Basic Information
| ChEMBL ID | CHEMBL506286 |
| Name | BASTADIN 19 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AHBBQQLIUBAPCY-DCRHPOARSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
1019.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HUVEC CHEMBL613979 | IC50 | 6.92 | 6.92 | 120.0 | 1 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 5.88 | 5.88 | 1310.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HUVEC | IC50 | = | 120.0 | nM | 6.92 | Antiproliferative activity against bFGF-treated HUVEC | - |
| Trypanosoma brucei brucei | IC50 | = | 1310.0 | nM | 5.88 | Antitrypanosomal activity against Trypanosoma brucei brucei 221 after 48 hrs by ... | 20102170 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18851910 | 10.1016/j.bmcl.2008.09.080 | Ryanodine receptor 1 | 1 |
| 8988595 | 10.1021/np960507g | Ryanodine receptor 1 | 1 |
| 20102170 | 10.1021/np9005986 | Trypanosoma brucei brucei | 1 |
| 20102170 | 10.1021/np9005986 | HCT-116 | 1 |
| - | 10.1039/C2MD20199B | Unchecked | 1 |
| - | 10.1039/C2MD20199B | HUVEC | 1 |
Data from ChEMBL 36 via Core Engine