Assay Detail
Functional
CHEMBL1112436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei 221 after 48 hrs by ATP-bioluminescence assay
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Additional insights on the bastadins: isolation of analogues from the sponge Ianthella cf. reticulata and exploration of the oxime configurations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 7 | - | - |
| IC50 | 2 | 5.82 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506286 | BASTADIN 19 | — | 1 | 5.88 |
| CHEMBL445712 | BASTADIN 13 | — | 1 | 5.75 |
| CHEMBL1628273 | BASTADIN 2 | — | 1 | - |
| CHEMBL1076810 | — | — | 1 | - |
| CHEMBL508857 | BASTADIN 8 | — | 1 | - |
| CHEMBL360190 | BASTADIN 7 | — | 1 | - |
| CHEMBL510730 | BASTADIN 6 | — | 1 | - |
| CHEMBL439151 | BASTADIN 5 | — | 1 | - |
| CHEMBL455487 | BASTADIN 4 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506286 | BASTADIN 19 | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL445712 | BASTADIN 13 | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL1628273 | BASTADIN 2 | Activity | - | — | - | |
| CHEMBL1076810 | — | Activity | - | — | - | |
| CHEMBL508857 | BASTADIN 8 | Activity | - | — | - | |
| CHEMBL360190 | BASTADIN 7 | Activity | - | — | - | |
| CHEMBL510730 | BASTADIN 6 | Activity | - | — | - | |
| CHEMBL439151 | BASTADIN 5 | Activity | - | — | - | |
| CHEMBL455487 | BASTADIN 4 | Activity | - | — | - |