Assay Detail
ADMET
CHEMBL1006271
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Cytotoxicity against human MRC5 SV2 cells after 72 hrs by resazurin-based fluorometric assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.16 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484328 | — | — | 1 | 6.43 |
| CHEMBL483744 | — | — | 1 | 6.40 |
| CHEMBL514620 | — | — | 1 | 6.09 |
| CHEMBL473284 | — | — | 1 | 6.00 |
| CHEMBL519168 | — | — | 1 | 5.70 |
| CHEMBL473494 | — | — | 1 | 5.70 |
| CHEMBL501633 | — | — | 1 | 5.52 |
| CHEMBL473285 | — | — | 1 | 5.36 |
| CHEMBL484522 | 11-CHLORONEOCRYPTOLEPINE | — | 1 | 5.30 |
| CHEMBL449051 | — | — | 1 | 5.14 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 4.96 |
| CHEMBL484526 | — | — | 1 | 4.85 |
| CHEMBL515592 | — | — | 1 | 4.82 |
| CHEMBL519342 | — | — | 1 | 4.82 |
| CHEMBL473490 | — | — | 1 | 4.80 |
| CHEMBL516390 | — | — | 1 | 4.80 |
| CHEMBL473286 | — | — | 1 | 4.75 |
| CHEMBL473491 | — | — | 1 | 4.70 |
| CHEMBL484527 | — | — | 1 | 4.70 |
| CHEMBL485019 | — | — | 1 | 4.68 |
| CHEMBL514022 | — | — | 1 | 4.68 |
| CHEMBL484723 | — | — | 1 | 4.57 |
| CHEMBL519350 | — | — | 1 | 4.54 |
| CHEMBL484523 | — | — | 1 | 4.47 |
| CHEMBL440898 | — | — | 1 | - |
| CHEMBL521328 | — | — | 1 | - |
| CHEMBL118916 | — | — | 1 | - |
| CHEMBL519152 | — | — | 1 | - |
| CHEMBL521169 | — | — | 1 | - |
| CHEMBL484524 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484328 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL483744 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL514620 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL473284 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL519168 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL473494 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL501633 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL473285 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL484522 | 11-CHLORONEOCRYPTOLEPINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL449051 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL484526 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL515592 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL519342 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL516390 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL473490 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL473286 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL473491 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL484527 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL485019 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL514022 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL484723 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL519350 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL484523 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL484131 | — | IC50 | < | 250.0 | nM | - |
| CHEMBL484132 | — | IC50 | < | 250.0 | nM | - |
| CHEMBL474905 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL474904 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL484724 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL474707 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL474910 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL475106 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL484524 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL521169 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL519152 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL118916 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL521328 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL440898 | — | IC50 | > | 32000.0 | nM | - |