Assay Detail
Binding
CHEMBL1006447
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Inhibition of human recombinant MMP1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.90 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11306 | — | — | 1 | 7.60 |
| CHEMBL452083 | — | — | 1 | 6.19 |
| CHEMBL501715 | — | — | 1 | - |
| CHEMBL452082 | — | — | 1 | - |
| CHEMBL452584 | — | — | 1 | - |
| CHEMBL510082 | — | — | 1 | - |
| CHEMBL445994 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11306 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL452083 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL501715 | — | IC50 | = | 270000.0 | nM | - |
| CHEMBL452082 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL452584 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL510082 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL445994 | — | IC50 | - | — | - |