Assay Detail
Functional
CHEMBL1006486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.55 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | — | 1 | 6.64 |
| CHEMBL453856 | ISOBUTYLALKANNIN | — | 1 | 6.52 |
| CHEMBL112415 | ACETYLALKANNIN | — | 1 | 6.47 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | — | 1 | 6.47 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | — | 1 | 6.43 |
| CHEMBL507545 | — | — | 1 | 6.41 |
| CHEMBL453082 | ETHYLSHIKONIN | — | 1 | 6.35 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 6.35 |
| CHEMBL11475 | — | — | 1 | 5.92 |
| CHEMBL289277 | EMODIN | — | 1 | 5.24 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | 5.06 |
| CHEMBL507566 | — | — | 1 | 5.04 |
| CHEMBL418068 | RHEIN | — | 1 | 4.89 |
| CHEMBL521045 | — | — | 1 | 4.83 |
| CHEMBL42624 | PHYSCION | — | 1 | 4.72 |
| CHEMBL41092 | CHRYSOPHANOL | — | 1 | 4.32 |
| CHEMBL2368547 | Sennoside A | — | 1 | 4.17 |
| CHEMBL454428 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL453856 | ISOBUTYLALKANNIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL112415 | ACETYLALKANNIN | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL507545 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL453082 | ETHYLSHIKONIN | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL11475 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL289277 | EMODIN | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL40275 | ALOE-EMODIN | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL507566 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL418068 | RHEIN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL521045 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL42624 | PHYSCION | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL41092 | CHRYSOPHANOL | IC50 | = | 47400.0 | nM | 4.32 |
| CHEMBL2368547 | Sennoside A | IC50 | = | 68200.0 | nM | 4.17 |
| CHEMBL454428 | — | IC50 | = | 75000.0 | nM | 4.12 |