Assay Detail
Binding
CHEMBL1006687
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Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.83 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.80 |
| CHEMBL341474 | — | — | 1 | 6.86 |
| CHEMBL511555 | — | — | 1 | 6.35 |
| CHEMBL466462 | — | — | 1 | 6.32 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 5.80 |
| CHEMBL523716 | — | — | 1 | - |
| CHEMBL468498 | — | — | 1 | - |
| CHEMBL136978 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL341474 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL511555 | — | Ki | = | 446.0 | nM | 6.35 |
| CHEMBL466462 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 1584.0 | nM | 5.80 |
| CHEMBL523716 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL468498 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL136978 | — | Ki | > | 10000.0 | nM | - |