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Assay Detail

CHEMBL1006832

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene.
Pettit GR, Anderson CR, Gapud EJ, Jung MK, Knight JC, Hamel E, Pettit RK.
J Nat Prod (2005) 68 : 1191 -1197
PubMed 16124759 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
GI50 11 - -
IC50 4 8.16 10.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL39541 DOLASTATIN-10 2.0 1 10.08
CHEMBL67 COMBRETASTATIN A4 -1.0 1 7.96
CHEMBL506246 1 7.44
CHEMBL147075 1 7.17
CHEMBL503466 1 -
CHEMBL455092 1 -
CHEMBL486595 1 -
CHEMBL485996 1 -
CHEMBL452813 1 -
CHEMBL456682 1 -
CHEMBL485995 1 -
CHEMBL486184 1 -
CHEMBL1627102 1 -
CHEMBL447074 1 -
CHEMBL359307 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL39541 DOLASTATIN-10 IC50 = 0.083 nM 10.08
CHEMBL67 COMBRETASTATIN A4 IC50 = 11.0 nM 7.96
CHEMBL506246 IC50 = 36.0 nM 7.44
CHEMBL147075 IC50 = 68.0 nM 7.17
CHEMBL503466 GI50 = 0.032 ug.mL-1 -
CHEMBL455092 GI50 = 0.07 ug.mL-1 -
CHEMBL486595 GI50 = 0.08 ug.mL-1 -
CHEMBL485996 GI50 = 0.33 ug.mL-1 -
CHEMBL452813 GI50 = 0.38 ug.mL-1 -
CHEMBL456682 GI50 = 0.39 ug.mL-1 -
CHEMBL485995 GI50 = 3.0 ug.mL-1 -
CHEMBL486184 GI50 > 1.0 ug.mL-1 -
CHEMBL1627102 GI50 > 1.0 ug.mL-1 -
CHEMBL447074 GI50 > 10.0 ug.mL-1 -
CHEMBL359307 GI50 = 0.028 ug.mL-1 -