Assay Detail
Functional
CHEMBL1006912
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Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.78 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.16 |
| CHEMBL465475 | — | — | 1 | 5.92 |
| CHEMBL294323 | — | — | 1 | 5.92 |
| CHEMBL507001 | DIOSCIN | — | 1 | 5.75 |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | 5.10 |
| CHEMBL512065 | OCHRACEOLIDE A | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL465475 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL294323 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL507001 | DIOSCIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL512065 | OCHRACEOLIDE A | IC50 | = | 14800.0 | nM | 4.83 |