Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL614917 Target Snapshot

SK-MEL-2 · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
42,368Compounds
1,241Assays
34Approved Drugs
1,425.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SK-MEL-2 as ChEMBL target CHEMBL614917. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SK-MEL-2
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614917
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SK-MEL-2 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSK-MEL-2
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSK-MEL-2
UniProt AccessionN/A

SK-MEL-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SK-MEL-2.

Review nameSK-MEL-2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

34
Approved
18
Phase III
22
Phase II
10
Phase I
Assay Mix

Activity Type Distribution

IC501,358.0
EC5067.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL139545 9.7 IC50 0.2 Preclinical
CHEMBL96926 9.53 IC50 0.2947 Preclinical
CHEMBL396373 9.52 IC50 0.3 Preclinical
CHEMBL266584 9.4 IC50 0.4 Preclinical
CHEMBL53463 9.0 IC50 1.0 Approved
CHEMBL4789549 8.92 IC50 1.2 Preclinical
CHEMBL3545252 8.77 IC50 1.701 Approved
CHEMBL1090479 8.7 EC50 2.0 Preclinical
CHEMBL259989 8.7 IC50 2.0 Preclinical
CHEMBL289615 8.7 IC50 2.0 Preclinical
Distribution

pChEMBL Value Distribution

199
5.0
148
5.5
85
6.0
56
6.5
31
7.0
24
7.5
19
8.0
10
8.5
3
9.0
3
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
Properties Compare Identifier
BINIMETINIB
CHEMBL3187723
Approved 2018
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
IRINOTECAN
CHEMBL481
Approved 1996
Properties Compare Identifier
TOPOTECAN
CHEMBL84
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

1,241
Total Assays
825
Tested Compounds
2
Assay Types
Functional — 1,230 assays, 825 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,193 825 5.6
organism-based format 37 0 —
ADME — 11 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 10 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine