Assay Detail
Functional
CHEMBL1006986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.53 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491667 | — | — | 1 | 8.72 |
| CHEMBL521964 | — | — | 1 | 8.24 |
| CHEMBL815 | DINOPROST | 4.0 | 1 | 7.61 |
| CHEMBL1050 | LATANOPROST ACID | -1.0 | 1 | 7.50 |
| CHEMBL491474 | — | — | 1 | 7.28 |
| CHEMBL489109 | — | — | 1 | 7.21 |
| CHEMBL491475 | — | — | 1 | 7.16 |
| CHEMBL523143 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491667 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL521964 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL815 | DINOPROST | EC50 | = | 24.5 | nM | 7.61 |
| CHEMBL1050 | LATANOPROST ACID | EC50 | = | 31.7 | nM | 7.50 |
| CHEMBL491474 | — | EC50 | = | 52.4 | nM | 7.28 |
| CHEMBL489109 | — | EC50 | = | 62.2 | nM | 7.21 |
| CHEMBL491475 | — | EC50 | = | 68.6 | nM | 7.16 |
| CHEMBL523143 | — | EC50 | = | 294.0 | nM | 6.53 |