Assay Detail
Functional
CHEMBL1007028
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Induction of apoptosis in human SNU398 cells assessed as caspase activation by HTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-398 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.19 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460601 | — | — | 1 | 7.36 |
| CHEMBL496732 | — | — | 1 | 7.13 |
| CHEMBL495560 | — | — | 1 | 6.77 |
| CHEMBL495768 | — | — | 1 | 6.48 |
| CHEMBL451938 | — | — | 1 | 6.28 |
| CHEMBL495911 | — | — | 1 | 6.25 |
| CHEMBL495912 | — | — | 1 | 6.24 |
| CHEMBL495561 | — | — | 1 | 6.14 |
| CHEMBL521706 | — | — | 1 | 6.12 |
| CHEMBL460602 | — | — | 1 | 6.01 |
| CHEMBL495910 | — | — | 1 | 5.82 |
| CHEMBL496939 | — | — | 1 | 5.46 |
| CHEMBL495562 | — | — | 1 | 5.33 |
| CHEMBL495978 | — | — | 1 | 5.28 |
| CHEMBL498210 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460601 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL496732 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL495560 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL495768 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL451938 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL495911 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL495912 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL495561 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL521706 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL460602 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL495910 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL496939 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL495562 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL495978 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL498210 | — | EC50 | > | 10000.0 | nM | - |