Assay Detail
Functional
CHEMBL1007085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 45 | 6.65 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 9.08 |
| CHEMBL470857 | — | — | 1 | 7.41 |
| CHEMBL256418 | — | — | 1 | 7.26 |
| CHEMBL523149 | — | — | 1 | 7.03 |
| CHEMBL473495 | — | — | 1 | 6.89 |
| CHEMBL469610 | — | — | 1 | 6.89 |
| CHEMBL446806 | — | — | 1 | 6.85 |
| CHEMBL473702 | — | — | 1 | 6.82 |
| CHEMBL472089 | — | — | 1 | 6.80 |
| CHEMBL270964 | — | — | 1 | 6.77 |
| CHEMBL491726 | — | — | 1 | 6.70 |
| CHEMBL479341 | — | — | 1 | 6.66 |
| CHEMBL491891 | — | — | 1 | 6.62 |
| CHEMBL272383 | — | — | 1 | 6.60 |
| CHEMBL471060 | — | — | 1 | 6.58 |
| CHEMBL409718 | — | — | 1 | 6.58 |
| CHEMBL479530 | — | — | 1 | 6.50 |
| CHEMBL513419 | — | — | 1 | 6.43 |
| CHEMBL490733 | — | — | 1 | 6.41 |
| CHEMBL488224 | — | — | 1 | 6.32 |
| CHEMBL516209 | — | — | 1 | 6.31 |
| CHEMBL470858 | — | — | 1 | 6.14 |
| CHEMBL272584 | — | — | 1 | 6.14 |
| CHEMBL472090 | — | — | 1 | 6.12 |
| CHEMBL445481 | — | — | 1 | 6.10 |
| CHEMBL479342 | — | — | 1 | 6.08 |
| CHEMBL455773 | — | — | 1 | 6.05 |
| CHEMBL273006 | — | — | 1 | 6.01 |
| CHEMBL271945 | — | — | 1 | - |
| CHEMBL479727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 0.84 | nM | 9.08 |
| CHEMBL470857 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL256418 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL523149 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL473495 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL469610 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL446806 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL473702 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL472089 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL270964 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL491726 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL479341 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL491891 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL272383 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL409718 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL471060 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL479530 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL513419 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL490733 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL488224 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL516209 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL272584 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL470858 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL472090 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL445481 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL479342 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL455773 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL273006 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL469821 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL511968 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL469396 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL469395 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL472293 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL515397 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL473493 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL452134 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL270026 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL470856 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL271574 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL470292 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL521406 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL492401 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL452696 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL479727 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL271945 | — | EC50 | > | 1000.0 | nM | - |