Assay Detail
Functional
CHEMBL1007108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at dog recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
21
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-3 adrenergic receptor (CHEMBL4400) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 8.76 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469395 | — | — | 2 | 9.20 |
| CHEMBL470856 | — | — | 1 | 9.17 |
| CHEMBL469821 | — | — | 1 | 9.06 |
| CHEMBL452134 | — | — | 1 | 9.00 |
| CHEMBL515397 | — | — | 2 | 9.00 |
| CHEMBL471060 | — | — | 1 | 8.96 |
| CHEMBL271574 | — | — | 1 | 8.92 |
| CHEMBL446806 | — | — | 2 | 8.92 |
| CHEMBL488224 | — | — | 2 | 8.90 |
| CHEMBL445481 | — | — | 1 | 8.85 |
| CHEMBL270026 | — | — | 1 | 8.66 |
| CHEMBL492401 | — | — | 1 | 8.60 |
| CHEMBL469396 | — | — | 1 | 8.54 |
| CHEMBL271945 | — | — | 1 | 8.54 |
| CHEMBL473702 | — | — | 1 | 8.49 |
| CHEMBL470292 | — | — | 1 | 8.00 |
| CHEMBL491726 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469395 | — | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL470856 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL469395 | — | EC50 | = | 0.83 | nM | 9.08 |
| CHEMBL469821 | — | EC50 | = | 0.88 | nM | 9.06 |
| CHEMBL452134 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL515397 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL471060 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL271574 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL446806 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL488224 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL446806 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL488224 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL445481 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL270026 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL492401 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL469396 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL271945 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL473702 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL515397 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL470292 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL491726 | — | EC50 | = | 10.0 | nM | 8.00 |