Assay Detail
Functional
CHEMBL1007111
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Inhibition of carbachol-induced increase in intravesical pressure in intraduodenally dosed Beagle dog OAB model for 30 mins measured for 180 mins
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 13 | - | - |
| EC50 | 13 | 8.11 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446806 | — | — | 2 | 8.92 |
| CHEMBL473702 | — | — | 2 | 8.74 |
| CHEMBL488224 | — | — | 2 | 8.40 |
| CHEMBL471060 | — | — | 2 | 8.15 |
| CHEMBL470856 | — | — | 2 | 8.09 |
| CHEMBL271574 | — | — | 2 | 7.95 |
| CHEMBL469821 | — | — | 2 | 7.85 |
| CHEMBL270026 | — | — | 2 | 7.73 |
| CHEMBL271945 | — | — | 2 | 7.70 |
| CHEMBL445481 | — | — | 2 | 7.58 |
| CHEMBL515397 | — | — | 2 | - |
| CHEMBL469395 | — | — | 2 | - |
| CHEMBL469396 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446806 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL473702 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL488224 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL471060 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL470856 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL271574 | — | EC50 | = | 11.2 | nM | 7.95 |
| CHEMBL469821 | — | EC50 | = | 14.2 | nM | 7.85 |
| CHEMBL270026 | — | EC50 | = | 18.7 | nM | 7.73 |
| CHEMBL271945 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL445481 | — | EC50 | = | 26.5 | nM | 7.58 |
| CHEMBL515397 | — | ED50 | - | — | - | |
| CHEMBL515397 | — | EC50 | - | — | - | |
| CHEMBL469395 | — | ED50 | - | — | - | |
| CHEMBL469395 | — | EC50 | - | — | - | |
| CHEMBL469396 | — | ED50 | - | — | - | |
| CHEMBL469396 | — | EC50 | - | — | - | |
| CHEMBL471060 | — | ED50 | = | 0.0349 | mg.kg-1 | - |
| CHEMBL473702 | — | ED50 | = | 0.0161 | mg.kg-1 | - |
| CHEMBL469821 | — | ED50 | = | 0.0247 | mg.kg-1 | - |
| CHEMBL271574 | — | ED50 | = | 0.047 | mg.kg-1 | - |
| CHEMBL470856 | — | ED50 | = | 0.0145 | mg.kg-1 | - |
| CHEMBL270026 | — | ED50 | = | 0.0459 | mg.kg-1 | - |
| CHEMBL445481 | — | ED50 | = | 0.0162 | mg.kg-1 | - |
| CHEMBL446806 | — | ED50 | = | 0.0143 | mg.kg-1 | - |
| CHEMBL271945 | — | ED50 | = | 0.0259 | mg.kg-1 | - |
| CHEMBL488224 | — | ED50 | = | 0.065 | mg.kg-1 | - |