Assay Detail
Functional
CHEMBL1007257
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Agonist activity at VDR assessed as receptor transactivation by transient transcription assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.11 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL467212 | — | — | 1 | 10.70 |
| CHEMBL466792 | — | — | 1 | 9.00 |
| CHEMBL452878 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL467212 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL466792 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL452878 | — | EC50 | = | 24.0 | nM | 7.62 |