Assay Detail
Binding
CHEMBL1007397
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Blockade of cathepsin G processing in human U937 cells by densitometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.44 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515494 | — | — | 1 | 7.05 |
| CHEMBL516292 | — | — | 1 | 6.82 |
| CHEMBL63440 | ALOXISTATIN | 2.0 | 1 | 5.96 |
| CHEMBL1162477 | — | — | 1 | 5.92 |
| CHEMBL478737 | — | — | 1 | - |
| CHEMBL1162478 | — | — | 1 | - |
| CHEMBL400387 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515494 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL516292 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL63440 | ALOXISTATIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1162477 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL478737 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1162478 | — | IC50 | - | — | - | |
| CHEMBL400387 | — | IC50 | > | 50000.0 | nM | - |