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Assay Detail

CHEMBL1007540

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Functional
Inhibition of staphyloxanthin biosynthesis in Staphylococcus aureus isolate Pig1 after 72 hrs by spectrophotometry
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Staphylococcus aureus
Confidence 1 — Organism
Curated By Autocuration

Target

Staphylococcus aureus (CHEMBL352)
Type ORGANISM
Organism Staphylococcus aureus

Publication

Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
Song Y, Liu CI, Lin FY, No JH, Hensler M, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AH, Oldfield E.
J Med Chem (2009) 52 : 3869 -3880
PubMed 19456099 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.02 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL495624 1 8.10
CHEMBL497634 1 7.55
CHEMBL495623 1 7.40
CHEMBL497616 1 7.38
CHEMBL497617 1 6.96
CHEMBL497635 1 6.36
CHEMBL524084 1 5.52
CHEMBL525377 1 5.39
CHEMBL496801 1 5.38
CHEMBL497815 1 5.30
CHEMBL497618 1 5.07
CHEMBL497410 1 4.82
CHEMBL449115 1 4.55
CHEMBL496802 1 4.46
CHEMBL523897 1 -
CHEMBL498628 1 -
CHEMBL496803 1 -
CHEMBL447414 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL495624 IC50 = 8.0 nM 8.10
CHEMBL497634 IC50 = 28.0 nM 7.55
CHEMBL495623 IC50 = 40.0 nM 7.40
CHEMBL497616 IC50 = 42.0 nM 7.38
CHEMBL497617 IC50 = 110.0 nM 6.96
CHEMBL497635 IC50 = 440.0 nM 6.36
CHEMBL524084 IC50 = 3000.0 nM 5.52
CHEMBL525377 IC50 = 4100.0 nM 5.39
CHEMBL496801 IC50 = 4200.0 nM 5.38
CHEMBL497815 IC50 = 5000.0 nM 5.30
CHEMBL497618 IC50 = 8600.0 nM 5.07
CHEMBL497410 IC50 = 15000.0 nM 4.82
CHEMBL449115 IC50 = 28000.0 nM 4.55
CHEMBL496802 IC50 = 35000.0 nM 4.46
CHEMBL523897 IC50 = 200000.0 nM -
CHEMBL498628 IC50 > 500000.0 nM -
CHEMBL496803 IC50 > 500000.0 nM -
CHEMBL447414 IC50 > 500000.0 nM -